PhD student in Organic Synthesis
(ref. BAP-2025-499)
Laatst aangepast: 11/08/25
Laatst aangepast: 11/08/25
The Laboratory of Chemical Biology at the KU Leuven works on the development of chemical probes for covalent labeling of proteins as well as methods to study membrane-embedded enzymes. We utilize an interdisciplinary approach with techniques of organic chemistry, biochemistry, cell biology and proteomics to unravel functions of disease-relevant enzymes.
Project
Proteases cut proteins not only during digestion but also in regulatory processes. Lack of precise control may lead to human disease. Some proteases exert a non-catalytic function beside their canonical proteolytic activity. Hence, inhibition is not sufficient to target these proteases in disease context. In this project, we aim to develop small molecules that degrade extracellular or membrane-bound proteases that are implied in cancer. We will do so by targeting them for endolysosomal uptake and destruction in the lysosomes
In this PhD project at KU Leuven, the focus lies on development carbohydrate-based ligands for lysosomal targeting and their conjugation to small molecules targeting membrane-anchored proteases. You will be responsible for the design and synthesis of these molecules, and will also be involved in their evaluation. This project is supported by a second PhD student in cell biology in Leuven and one in organic synthesis and biochemistry in Wroclaw
In this PhD project at KU Leuven, the focus lies on development carbohydrate-based ligands for lysosomal targeting and their conjugation to small molecules targeting membrane-anchored proteases. You will be responsible for the design and synthesis of these molecules, and will also be involved in their evaluation. This project is supported by a second PhD student in cell biology in Leuven and one in organic synthesis and biochemistry in Wroclaw
Profile
- MSc degree in chemistry or chemical biology
- Experience with organic synthesis is a must, preferably on carbohydrates or derivatives
- Enjoyment of challenges; proactive in seeking for solutions
- Interest in biochemistry and cell biology
- Good team player in internationally-oriented environment
- Excellent English communication skills
- Ambitious, motivated, creative and practically skillful
Offer
We offer a doctoral position for 4 years in a stimulating, interdisciplinary environment. You will have scientific development opportunities in an international and dynamic team. You will have access to state-of-the-art research facilities and will be registered in a specific program of the KU Leuven doctoral school of Biomedical Sciences.
www.verhelstlab.net
Interested?
For more information please contact Prof. dr. Steven Verhelst, tel.: +32 16 37 45 17, mail: steven.verhelst@kuleuven.be.
You can apply for this job no later than September 03, 2025 via the online application tool
KU Leuven strives for an inclusive, respectful and socially safe environment. We embrace diversity among individuals and groups as an asset. Open dialogue and differences in perspective are essential for an ambitious research and educational environment. In our commitment to equal opportunity, we recognize the consequences of historical inequalities. We do not accept any form of discrimination based on, but not limited to, gender identity and expression, sexual orientation, age, ethnic or national background, skin colour, religious and philosophical diversity, neurodivergence, employment disability, health, or socioeconomic status. For questions about accessibility or support offered, we are happy to assist you at this email address.
Heb je een vraag over de online sollicitatieprocedure? Raadpleeg onze veelgestelde vragen of stuur een e-mail naar solliciteren@kuleuven.be
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Tewerkstellingspercentage: Voltijds
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Locatie: Leuven
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Solliciteren tot en met:03/09/2025 23:59 CET
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Tags: Chemie